StormJib said:
First check to see what you have with American Express. For many of us there are very solid reasons to only use American Express for airline tickets. Not all the cards are equal so you must check your own benefits and you must use The Card to get the benefits. Maybe you can get that from VISA or MC but I have not found it.

Two, if you do not automatically have it from American Express? For us the most important benefit is global coverage that allows you to get an American doctor on the phone 24/7 and if you have any issues that require significant treatment a medically equipped airplane will be sent to get you home and to your care. My experience is not the risk and cost of treatment you can get locally on a trip. The cost and risk is transportation if you want or need to go home for significant care. If anyone in your group gets real sick you will want to see that plane to get you home. That all starts with a service that gets a US physician on the phone 24/7 to review your symptoms and possible treatment. They will either refer you to a local doctor known to them or come get you.