Not sure exact dates and where you are headed first, but we found flying into PISA offered us the best price. In fact we flew into Pisa with a stop in Paris and out of Milan direct to DC (IAD)- The trip was an Air France/Delta was about $850.
If you are headed to Lake Como and Lerici investigate going and coming out of a different airport. Just bookend those destinations. Stay away from traveling Sunday and Monday going to Europe - prices seem insane and usually businessman drive the price. Round Trips from the same airport is not always the cheapest these days.
Happy Hunting.