Certainly possible, but definitely should have a plan B prepared. We last returned to US through CLT in June - as usual, CLT worked pretty well. But, other than arrival time (usually at least a little early), delays can happen at immigration, luggage collection/rechecking, and security check, and then the question of how far to go to departure gate. Your friend will not need to wait for luggage which helps a lot. Issue will be immigration (which probably will not be too bad on Wednesday evening) and clearing security (which is the wild card). When we came through in June, they were restricting use of security check point closest to where you come up from lower level where you clear immigration and customs. No idea what was going on with that - hopefully will not be case for your friend. Overall, assuming your friend is able to move quickly, I would say "go for it" but have a definite plan B.

Edited to add that our last through CLT was on June 22 - a Wednesday.