Malaria is a risk in many tropical countries and, though prophylaxis is available, it is never 100%. Some of the drugs used for prophylaxis may also have side effects varying from digestive upsets to serious neurological problems - the incidence of side effects is low but they can mess up your holiday and have long lasting effects. You are taking a risk and only you can decide whether the rewards justify the risks.
From my personal experience, one of the drugs used is Lariam (Mefloquine) and my sister suffered serious side effects from it that stopped her being able to work for about 5 years. Many people (including me) have taken Lariam and suffered no side effects. Search the web if you want more information.
I'm sure your physician will be able to offer you up-to-date advice on the areas with higher or lower risks and/or the appropriate drug regimes.
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