5 days isn't a lot of time, but I have always done self drive. There could be a lot of value with a guide. Driving is very easy as the roads and drivers are very good.

On visiting Table Mtn, don't plan a specific date/time as the clouds can roll in FAST and it isn't worth the visit.

In the wine area we generally stay at Grande Provence grandeprovence.co.za, it is the nicest place, and not too expensive, just looks expensive.

Driving the Garden Route is always fun, that that alone could take 5 days.

A decent drive from CPT is Oudshorne and the Cango Wildlife Ranch cango.co.za it is a Cheetah conservation facility. We donated some money years ago and are lifetime members (not that much money), the behind the scene tours you get are awesome. A very different experience from the game drives.

As Greg mentioned, Simons Town is pretty cool, strange enough it looks like the Baths in BVI.

People don't realize how much there is to do in SA. Every area is different, CPT is like San Diego, Jo-berg area is like Kansas, etc....