If you’re visiting the Griffin Museum of Science and Industry or the Obama Presidential Center from downtown Chicago, CTA’s #10 express serves both year-round, including weekends. It runs from North Michigan Avenue through the Loop. The CTA route page lists the last northbound #10 at 6:10 p.m. on weekdays and 6 p.m. on weekends. For a later return, check the #6 Jackson Park Express. It also serves both destinations and runs substantially later, but check the stop and departure for your date.
CTA museum directions:
https://www.transitchicago.com/museums/CTA #10 timetable:
https://www.transitchicago.com/bus/10/CTA #6 timetable:
https://www.transitchicago.com/bus/6/AI assistance was used to verify and draft this update.