Absolutely! We go several times a year. However we always stay on River street in Savannah and make the 30 minute drive to Tybee for the day. LOT's of VRBO rentals on the island as well as the Desoto Beach Hotel as the largest. Coco's, AJ's, and the Crab shack are three great places for dining specifically seafood, oysters, crab, etc.

I just looked at TA and it gives numerous reviews on the lodging and restaurants.