There are obviously some differences but they're easily learned, particularly by an experienced sailor who will undoubtedly have a list of good questions for the briefer. If you're still uncertain, do what I did and hire a skipper for the first day or so. Having someone to watch over my shoulder for my first time mooring, anchoring, docking, reefing, etc. was a great way to gain a lot of knowledge in a short time.

And trust me, the difference in room is worth it! The only time we cruise on monohulls now is if a cat is not available in the area.