You will have no problem with the CPAP. In fact , you are not supposed to pack the machine. You should carry it in the open so that it can be seen and examined, it needed, separately by TSA. For those that mentioned different waters, you should stay with distilled water. In fact cruise ships and many reputable hotel will supply you with distilled water in your cabin/room. The CPAP machine is a medical device that can keep you alive wile you sleep.