HI, lots of good advice given.
My comments
To a 1st time visitor, there is some acclimatization needed, once you’ve been 2 – 3 times, all the suggestions and locations make more sense than not having visited or even one time for a week, so I’m guessing some of the advice can be overwhelming in choices given.

AI – our first 2 visits were to the Sonesta Maho, 1st time a last minute radio contest win, we were basically clueless about the island, two nice ladies from Rubbermaid helped us out with info. Second time we had done some homework and came armed with a map and took a car ride around the island checking out locations to stay, eat and beach.
The following yr we stayed at the Royal Islander LaPlage next to the Maho hotel [found the previous yr!]and have gone from there, now liking staying at Orient village. It’s all a matter of taste of what you want in your visit.

If I had only a wk and had a deal at the Sonesta Great Bay n P’burg I might consider it, using it as a base to explore. Bkfast no fuss, lunch out, some dinners in after long beach days. Not for everyone but might be workable.
Suggestions – not sure length of visit or budget, but my suggestions based on a one wk stay.

I notice on the owners assoc page the Royal Islander LaPlage has a 6th floor 2 bed penthouse for a wk in July for $1500. I would consider that for a 1st time visit. The location gives you some immediate beach, easy access to Mullet beach [walk or drive], walking distance to several good resto’s and an easy drive to more great resto’s in Cupecoy and into Simpson Bay. Easy day time drive to other beaches to try like Baie Rouge [a new fav of ours] and Orient. It’s also minutes from the airport and has change facilities for your last day when you have vacated your room. Casino is across the street and cabs are easy to get if needed from the Maho hotel next door.

My other choice would be something in Orient Village, easy drive or better yet a walk to the Village sq, lots of excellent resto choices, easy cab ride to Grand Case for more resto choice’s. Either easy drive or walk to Orient beach, lots of choice on the beach for food and rec. Many villa choices with pools for you to choose from in the area. Loved walking on the beach in the morning and stopping to get croissants for our breakfast on the way back.

Those 2 choices would suit us, but you need to decide what is for you.

Note, unless staying in the Maho area, less than 5 minute cab ride [lots of cabs at the airport no need to prebook] and you want a car, I would arrange a cab to pick you from the airport the 1st day, have your rental delivered to where you are staying the next day – way easier and feels luxurious to us! Try Wilfred Brooks a sponsor. Also, if your unit allows it, suggest to use Jeannie from Shop n Drop to stock your unit with food and drink before your arrival – it’s your 25th, cab ride to the love nest topped off with a cold bottle of something special waiting for you hmmm...

You can’t lose on this trip
Enjoy
J&B