I wouldn't do it unless on one of the two mooring balls in front of Coco Loco. We stayed two nights there on 4/18 & 4/19 on a 50ft cat, although quite a few boats were anchored overnight up in the east end of the bay. As GeorgeC1 said, it can get ugly in there real quick as the bay is wide open to the southeast. We had a few gusts on the night of 4/19 and I was glad we were on a ball.