I would say BVI. Last trip we went from STT and on day 1 going to BVI my wife got very sea sick which is rare for her as she has been on boats often, The weather was not awful but significantly greater wave action that "in the BVI". Regarding St John, great place to visit on future trips. So many places in BVI you need multiple weeks.
I think the 40-45 ft will be great.

Wes
s/v Sea Tiger (2022 Lagoon 46)
www.BareBoatBVI.com