I am trying to verify if there are any hurdles for departing the BVI on a privately owned boat(US Flagged, based in BVI).
Email to C&I has not been answered yet (only been a few days).

I am aware of the USVI portal and plans would be to check into USVI at Cruz Bay. All are Vaccinated.

Specifically, is there anything needed prior to going to C&Ithe day before departure?

You cannot go to C&I on the day of your intended departure without an appointment.

You will need to contact Mr. Romney (gromney@gov.vg) in order to get pre-clearance. Once you have his permission, you will get an appointment at your intended port of departure.

Note that last year I waited over 2 weeks to get permission, despite having supplied all necessary forms and documents! He did nothing at all despite frequent e-mails and calls. In the end I cc'd my consular representative on the e-mail and, miraculously, I got permission to leave the next day! I think my case might have been an exception, as it was during the big COVID-19 outbreak and it seems that nobody was doing any work. Nonetheless, get your paperwork in order and get an appointment as early as possible so you won't be stuck in the BVI past your intended stay.

Thanks for your input.

Mr Romney did reply to me to use the SailClear.com site so I will submit ASAP.