I have been using Orbitz quite a bit lately as they offer a 15% discount above hotel rates, additional kickback of hotel/airline costs, and 5% to use their credit card--a combination that's hard to refuse.

Anyway, I have checked each of my three flights in the airlines reservation system to confirm that the res and appropriate traveller info got passed along properly. It did. I also needed to follow up with the hotels to make sure our room requests got entered properly in the hotels reservation system.

So, I always confirm with the airline/property that my booking is in their system, and that my special requests are properly noted.