The Anegada Passage is notoriously uncomfortable from the VI to SXM. Wind on the nose, in opposition to a westerly current, and sometimes a healthy northerly swell makes for short, steep, and confused seas. In a powercat you might feel like you're in a washing machine. Thus the moniker, Omygodapassage. Having a sail up would make a world of difference.

If you're bareboating, making the passage in the opposite direction would be preferred. If I had the choice, in a powercat, I'd wait for a calm weather window. Wind <10K and no northerly swell. Those conditions occur frequently in the summer.

The popular route around Necker is fine, but I'd just grit my teeth and head through Round Rock Passage - actually a straighter shot. Leave at dusk, and if you're lucky you'll see the lights of St. Martin just before the sun rises.