Driving the Garden Route is great, if you like Cheetahs, stop at Canga Wildlife Preserve, in Oudshorne, we sponsor O'Malley the Cheetah there and can arrange play dates.
The whales in Hermanus are fun to watch
The penguins At Simons town are fun, that area looks just like the Baths in BVI
Out that way Stanford River Lodge is a great place to stay - friends of ours.
in CapeTown, watch the weather for going to Table Mountain, the Table cloth (clouds) can quickly cover it.
If you want to do a game drive we recommend Ingwe Game Lodge in Houdspruit (easy to fly up there) Kruger is just too large.