We have been to Antigua several times and we have rented a car. (I am the type who likes to have a car and am comfortable driving on the left.) The traffic is not heavy.(just stay away from St. John) But the roads are rural -- meaning signage isn't great and at night lighting is not great. Also, because of the topography, the distances are farther than they look on a map. I agree with Irina about the English Harbour area -- that is my favourite area of Antigua. Check out the Antigua Yacht Club hotel, The Inn at English Harbour, Admiral's inn or Copper and Lumber Store.