My wife and have done a few charters together (just the 2 of us), although now we also have 2 teenagers to lend a hand, and often another family.

Really depends on your wife's comfort level as far as helping out - my wife didn't have many concerns on our charters with just the 2 of us (usually on a 38' cat), but she has sailed with me on our boat on San Francisco Bay for some time.

You know the charter boats - they are pretty much laid out for basic handling - if she is comfortable with taking the helm while you work the halyards, etc., she could likely manage if she has some sailing knowledge. And, most of the charter companies will even offer (for a fee, of course) a skipper for the first day, if you want someone to help "show her the ropes," so to speak, get her comfortable with handling the boat.