we have stayed all over the island and each area can feel completely different. As others have said we could use more info about what you like. Do you mind driving 20+minutes to the beach, restaurants or grocery stores? do you mind driving at night? would you prefer sunrise or sunset views? is there a price range for the villa?
Our favorite villa with equal masters is Villa Carolina, it's perched high up in Upper Carolina with amazing views of the BVI's and Coral Bay. I'm more of a sunrise person so I like it here! It's probably 5 minutes to Coral Bay, less than 10 minutes to the beach at Maho Bay and 20 minutes to Cruz Bay. I enjoy driving the island, especially the North Shore road, however driving Centerline Road at night from Cruz Bay is dark, curvy and boring! Check out the photo's in their website the big arched doorways open up the great room/kitchen to the infinity pool area, beautiful!
www.villacarolina-stjohn.com and they are on VRBO.
